Synthesis, Characterization, and Cytotoxic Activities of a Schiff Base Ligand and Its Binuclear Copper(II) and Manganese(III) Complexes

Authors : Zafer UYAR, Diğdem ERDENER, İsmail KOYUNCU, Ülkü ARSLAN

Pages : 963-980

Doi:10.18596/jotcsa.329108

View : 10 | Download : 6

Publication Date : 2017-09-21

Article Type : Research Paper

Abstract :A novel symmetrical N2O2 type Schiff base insert ignore into journalissuearticles values(1); and its copper insert ignore into journalissuearticles values(II); insert ignore into journalissuearticles values(2); and manganese insert ignore into journalissuearticles values(III); insert ignore into journalissuearticles values(3); complexes were synthesized and characterized by spectroscopic, analytical, and magnetic susceptibility studies. Spectroscopic and magnetic susceptibility studies suggested that copper and manganese ions are in 2+ and 3+ states and their complexes have a binuclear double stranded helical structure in the form of 2:2 insert ignore into journalissuearticles values(metal to ligand); stoichiometry. Cytotoxic effects of the ligand and its metal complexes against MCF-7 insert ignore into journalissuearticles values(human breast cancer cell line);, DLD-1 insert ignore into journalissuearticles values(human colorectal cancer cell line);, ECC-1 insert ignore into journalissuearticles values(human endometrium cancer cell line);, DU-145 insert ignore into journalissuearticles values(human prostate cancer line);, MDA-MB231 insert ignore into journalissuearticles values(human breast cancer cell line);, PC-3 insert ignore into journalissuearticles values(human prostate cancer line); and HEK293 insert ignore into journalissuearticles values(normal cells); were evaluated by determining their cellular viability using the colorimetric 3-insert ignore into journalissuearticles values(4,5- dimethylthiazole-2-yl);-2,5-biphenyl tetrazolium bromide insert ignore into journalissuearticles values(MTT); assay. It has been found that cytotoxicity of the ligand was significantly enhanced towards cancer cells and declined towards normal HEK293 cells by metal chelation. Copper complex yielded better results in comparison with manganese complex. Particularly, c opper complex showed a selective cytotoxicity, harming the cancerous cell lines while not impairing the normal cells, which is considered as the key to the future of cytotoxic therapy.
Keywords : N2O2 Schiff base, transition metal complexes, binuclear complexes, selective cytotoxicity, metal chelation