Chitosan-drug encapsulation as a potential candidate for COVID-19 drug delivery systems: A review

Authors : Onome EJEROMEDOGHENE, Olayinka ODERİNDE, George EGEJURU, Sheriff ADEWUYİ

Pages : 851-864

Doi:10.18596/jotcsa.773780

View : 11 | Download : 7

Publication Date : 2020-10-30

Article Type : Review Paper

Abstract :Since the outbreak of COVID-19, the World Health Organization insert ignore into journalissuearticles values(WHO);, Centre for Disease Control insert ignore into journalissuearticles values(CDC);, and other health organizations around the world have coordinated the flow of information and given out preventive directives measures and guidelines to reduce the impact and spread of the disease. Meanwhile, bodies of scientists and researchers around the world are still working ceaselessly to study the virus, mode of transmission mechanisms, and are rapidly developing therapeutic antiviral drugs and vaccines. Thus, the urgent need for the fabrication of biocompatible and biodegradable composite materials as drug delivery vehicles for the efficient loading, targeted delivery and controlled release of antiviral drugs to the target site is been inspired. Therefore, this review highlights the antimicrobial and antiviral activities of chitosan as well as the potency of a combined therapy via electrostatic/hydrogen bonding encapsulation onto the WHO suggested clinical trial drugs and possible chelation with metal ions to form new improved antiviral compounds as a promising agent for the targeted drug delivery.
Keywords : COVID 19, Biopolymeric chitosan, Antiviral agent, Drug delivery, Biocompatible, Antibiotics, Antibiotics