Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper

Authors : Kok Tong WONG, Hasnah OSMAN, Thaigarajan PARUMASİVAM, Jafri Malin ABDULLAH, Mohd. Zaheen HASSAN, Mohamad Nurul Azmi MOHAMAD TAİB

Pages : 995-1002

Doi:10.18596/jotcsa.904529

View : 12 | Download : 8

Publication Date : 2021-11-30

Article Type : Research Paper

Abstract :Bamboo shoots of Dendrocalamus asper is very important for human health because of its high content of dietary fiber, low sugar, negligible amount of fat, rich in vitamins and minerals. In search of new potential antimalarial agents, the chemical constituents of bamboo shoots were evaluated againts the P. falciparum strain 3D7. One new metabolite, insert ignore into journalissuearticles values(11E,13E,17E,19E);-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate insert ignore into journalissuearticles values(1); along with the four known compounds; β-sitosterol insert ignore into journalissuearticles values(2);, methyl-4-hydroxybenzoate insert ignore into journalissuearticles values(3);, 1-methoxy-4-insert ignore into journalissuearticles values(methoxymethyl);benzene insert ignore into journalissuearticles values(4); and 4-hydroxybenzaldehyde insert ignore into journalissuearticles values(5); were isolated from the crude extract using chromatographic methods: MPLC, UPLC/MS, analytical and preparative HPLC. Among these, compounds 1, 3 and 4 showed promising antimalarial activity with IC50 between 0.8-2.2 μg/mL. The molecular docking between the most potent compound 3 and dihydrofolate reductase-thymidylate synthase insert ignore into journalissuearticles values(DHFR-TS); was done to understand and exploring ligand-receptor interactions and hypothesize the compound`s refinements
Keywords : Dendrocalamus asper, antimalarial, P Falciparum, Molecular docking, dihydrofolate reductase thymidylate synthase DHFR TS,