Chitosan-Graft-Polyacrylamide Based Release Systems: Effect of pH and Crosslinking

Authors : Ahmet KÜÇÜKÇALIK, Cüneyt H. ÜNLÜ

Pages : 121-130

Doi:10.18596/jotcsa.968037

View : 13 | Download : 8

Publication Date : 2022-02-28

Article Type : Research Paper

Abstract :This study covers the synthesis and release behavior of chitosan-graft-polyacrylamide copolymers in aqueous media at different pH values. The copolymers were synthesized using redox polymerization with ceric ammonium nitrate insert ignore into journalissuearticles values(CAN); in 1% aqueous acetic acid solution as the initiator. Optimum condition for the graft copolymer synthesis was determined as 3.85 g/L chitosan, 0.27 M acrylamide insert ignore into journalissuearticles values(AAm); monomer at 40 °C with a CAN per gram chitosan as 6 mmol using 0.05 M stock solution in 0.1 N HNO3. Then the crosslinked copolymers were synthesized using methylenebisacrylamide insert ignore into journalissuearticles values(MBA); as a crosslinker varying mass proportions of AAm:MBA as 15:1, 20:1, and 30:1. Obtained material amount insert ignore into journalissuearticles values(polymer yield); and molecular weight of crosslinked copolymers were lower than the graft copolymer as expected. Acetylsalicylic acid insert ignore into journalissuearticles values(ASA); release behaviors of all copolymers were monitored with UV-visible spectroscopy at different pH values insert ignore into journalissuearticles values(2, 6, and 8.5); corresponding to different media in the body insert ignore into journalissuearticles values(stomach, skin, and intestine, respectively);. According to the results, the release behavior changed the least among the samples with respect to medium pH and of was the most affected.
Keywords : Drug Delivery Systems, Chitosan, Emulsion Polymerization, Graft Copolymers