Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Authors : Ghufran A. ALHAMMADİ, Lamya A. SARSAM

Pages : 193-204

Doi:10.18596/jotcsa.1158403

View : 7 | Download : 4

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol insert ignore into journalissuearticles values(BHA);, is used to evaluate Metoclopramide hydrochloride insert ignore into journalissuearticles values(MCP.H); by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and it\`s pharmaceutical preparation by utilizing BHA as a reagent, insert ignore into journalissuearticles values(MCP.H); azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg / 5 mL, insert ignore into journalissuearticles values(i.e. 4-56 ppm); with a good sensitivity insert ignore into journalissuearticles values(molar absorptivity 0.26x104 L.mol-1. cm-1);; good precision insert ignore into journalissuearticles values(RSD better than 0.844 %); and high accuracy insert ignore into journalissuearticles values(relative error less than + 0.4%);, Sandell\`s sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection insert ignore into journalissuearticles values(LOD); is 0.0658 µg/mL and the evaluated limit of quantitation insert ignore into journalissuearticles values(LOQ); is 0.2193 µg/mL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.
Keywords : butylated hydroxyanisole, metoclopramide hydrochloride, spectrophotomety, friendly environment