Investigation of Thermodynamic and Morphological Properties of Crystalline 4-HPG (4-hydroxyphenylglycine) Using Raman, PXRD and DTA/TGA

Authors : Mustafa Ergin

Pages : 889-898

Doi:10.18596/jotcsa.1369980

View : 40 | Download : 48

Publication Date : 2024-05-15

Article Type : Research Paper

Abstract :This study focuses on the detailed physical characterization of 4-HPG, a significant impurity found in some of the most commonly prescribed β-lactam antibiotics worldwide. Various analytical techniques, including X-ray powder diffractometry, dynamic light scattering, scanning electron microscopy, Fourier-transform infrared, and Raman spectroscopy, were employed to characterize the properties of 4-HPG crystals. XRD analysis revealed the crystallinity and small crystallite sizes of 4-HPG particles, supported by DLS and SEM analyses. FT-IR and Raman spectroscopy results exhibited excellent agreement, providing insight into the structural characterization of 4-HPG. Thermal analysis revealed a two-stage degradation feature of 4-HPG. Overall, this study contributes to a better understanding of 4-HPG\'s structure and its impact on antibiotic stability.
Keywords : 4 hydroxyphenylglycine, impurity, crystallization, pharmaceutical analysis, stability