Synthesis of Some New 1,3,4-Thiadiazole Derivatives Derived from Cholic Acid and Evaluation of their Biological Activity

Authors : Intisar Q M Alaraj, Rana A. Saeed, Linda Reyadh, Amena A. Ahmed

Pages : 425-432

Doi:10.18596/jotcsa.1371936

View : 703 | Download : 518

Publication Date : 2024-05-15

Article Type : Research Paper

Abstract :In this work, several oxadiazole, thiadiazole, and triazole derivatives, as well as new Schiff bases, were prepared. Cholic acid was used as a starting material to prepare the five-membered heterocyclic compounds. The synthesized compounds were identified by FTIR and 1H,13C-NMR spectroscopy, which elucidated and confirmed the structure of the target molecules. Estimation of the biological activity of the newly produced compounds has been conducted against two types of Gram-positive and Gram-negative pathogenic bacteria.
Keywords : Cholic acid, heterocyclic, Schiff bases, thiadiazoles, oxadiazoles, pathogenic bacteria