Kidney tissue selenium levels of Toxocara canis infected mice given Nigella sativa

Authors : Serkan SAYINER, Mehtap ALTAŞ, Güzin CAMKERTEN, Ahmet Özer ŞEHİRLİ, Nilgün PAKSOY, Burcu Menekşe BALKAN, Gülten ŞENOCAK SORAN

Pages : 278-283

Doi:10.31797/vetbio.977962

View : 17 | Download : 5

Publication Date : 2021-12-31

Article Type : Research Paper

Abstract :Nigella sativa insert ignore into journalissuearticles values(NS); has a protective effect on cellular damage caused by oxidative stress. Selenium has an antioxidative effect. Toxocara canis is one of the nematodes causing visceral larva migrans. Men infected with this parasite ingesting an embryonic egg. It is more common in children between 1-4 years than adults. From the ingested embryonic egg, the larvae released in the small intestine and they migrate to so many organs such as liver, spleen, kidney, lung, brain, retina of the eye, pancreas and causing lesions. In particular, it is known to cause intense damage to kidney tissue. In this study mice with Toxocara canis infection were administered Nigella sativa in prophylactic and treatment doses insert ignore into journalissuearticles values(100 and 200 mg/kg body weight); and selenium levels were determined in their kidney tissues. In the healthy control group, kidney selenium levels were 980,46±236,68 ng/g and in mice infected with Toxocara canis 1240,15±315,77 ng/g. Kidney tissue Se levels of mice given NS in two different doses for treatment insert ignore into journalissuearticles values(Treated N100, Treated N200); and prophylaxis insert ignore into journalissuearticles values(Prophylactic N100 and ProphylacticN200); respectively are 1297,95±354,37; 1361,29±410,46 ng/g; 1148,55±240,28 ng/g and 1465,81±450,25 ng/g. Kidney tissue selenium levels were high in both treatment and prophylaxis dose NS given mice. In conclusion, Nigella sativa can cause increases in kidney tissue selenium levels depends on given doses.
Keywords : Nigella sativa, Selenium, Oxidative stress, Kidney, Toxocara canis