Investigation of the effect of sodium selenite on metallothioneine expression in the liver and kidney in experimental cyclophosphamide toxicity

Authors : Mehmet KARABOĞA, Hamdi AVCI

Pages : 101-111

Doi:10.31797/vetbio.1285594

View : 38 | Download : 43

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :In this study, the effect of sodium selenite insert ignore into journalissuearticles values(SS); on metallothionine expression in liver and kidney tissues of rats administered cyclophosphamide insert ignore into journalissuearticles values(CP); at high dose intraperitoneally insert ignore into journalissuearticles values(i.p.); was investigated. In the study, a total of 24 Wistar Albino female rats with a weight of 200±10 g were used in 4 groups. Grouping in the study: Group I insert ignore into journalissuearticles values(Control group; daily 1 mL serum physiologique given as ip);, Group II insert ignore into journalissuearticles values(CP group; 200 mg/kg/day CP administered as ip for 1 day);, Group III insert ignore into journalissuearticles values(SS Group; 1 day ip 1 mg/kg/day SS was given as a treatment);, Group IV insert ignore into journalissuearticles values(CP Group + SS Group; 200 mg/kg/day CP and 1 mg/kg/day SS was given as ip for 1 day); by forming 4 different groups. The effect of histopathological findings was found to be significantly lower in the group in which CP was given at high doses and SS was applied at the same time, compared to the group in which only CP was applied. When immunohistochemical findings related to MTs of liver and kidney tissues in this group were compared with histopathological findings, similar results were observed in terms of evaluation results. The study was concluded to be important in terms of animal and human health because SS is well tolerated in the organism and has no side effects at the appropriate dose.
Keywords : selenyum, siklofosfamid, metallotiyonin