The Clinical Course of Infective Endocarditis and Independent Predictors of In-Hospital Mortality

Authors : Hakan ÇAKIR, Samet UYSAL, Ali KARAGÖZ, Cüneyt TOPRAK, Lütfi ÖCAL, Mehmet Yunus EMİROĞLU, Cihangir KAYMAZ

Pages : 115-121

View : 19 | Download : 4

Publication Date : 2022-08-20

Article Type : Research Paper

Abstract :Introduction: Despite advances in prevention, medical, and surgical treatment, the global prevalence of infective endocarditis insert ignore into journalissuearticles values(IE); has been gradually rising over the last two decades. However, the profile of IE varies by continent, geographic region, and hospital type. In this study, we aimed to investigate the epidemiological and clinical features of IE and to determine the factors predicting in-hospital mortality. Patients and Methods: This retrospective study was carried out at a single tertiary health care hospital in Türkiye. A total of 104 consecutive patients insert ignore into journalissuearticles values(>18 years old); who were hospitalized with IE between January 2016 and August 2021 were included. Modified Duke criteria were used to diagnose IE. Demographic information insert ignore into journalissuearticles values(age and gender);, underlying heart diseases, comorbidities, causative microorganisms, blood culture results, echocardiographic findings, cardiac and extracardiac complications, surgical requirements, and in-hospital mortality were all examined. Results: The study included 104 IE cases insert ignore into journalissuearticles values(mean age: 57.2 ± 15.9 years; 59.6% males);. Fifty-six patients insert ignore into journalissuearticles values(53.9%); had native valve IE, 37 patients insert ignore into journalissuearticles values(35.6%); had prosthetic valve IE, and four patients insert ignore into journalissuearticles values(3.8%); had devicerelated IE. Blood cultures were negative in 62 cases insert ignore into journalissuearticles values(59.6%);. Staphylococcus aureus was the most common responsible microorganism in 17 patients [methicillin-sensitive Staphylococcus aureus in 13 insert ignore into journalissuearticles values(12.5%);, methicillin-resistant Staphylococcus in four insert ignore into journalissuearticles values(3.8%);]. The overall in-hospital mortality rate was 30.8%. White blood cell count insert ignore into journalissuearticles values(OR= 1.002, 95% CI= 1.001-1.003); creatinine insert ignore into journalissuearticles values(OR= 1.45, 95% CI= 1.08-2.00);, acute renal failure insert ignore into journalissuearticles values(OR= 8.60, 95% CI= 2.27-37.81);, and cerebrovascular accidents insert ignore into journalissuearticles values(OR= 4.58, 95% CI= 1.21-18.85); were independent predictors of in-hospital mortality. Conclusion: In line with developed countries, the epidemiology and causative pathogens of IE in Türkiye have been changing. Investigating these epidemiological and clinical changes may serve as a basis for strategies to be developed for the prevention and treatment of IE.
Keywords : Infective endocarditis, microbiology, epidemiology, mortality