Sacubitril/Valsartan Treatment in Heart Failure Increases The Left Ventricular Ejection Fraction: A Bayesian Analysis

Authors : Oğuzhan BİRDAL, Mehmet SAYGI, Pınar DEMİR GÜNDOĞMUŞ, Emrah AKSAKAL, Flora ÖZKALAYCI

Pages : 250-256

View : 16 | Download : 4

Publication Date : 2022-12-01

Article Type : Research Paper

Abstract :Introduction: Heart failure is an important leading cause of mortality and morbidity despite optimal medical treatment and device therapy. Sacubitril/valsartan, a first-generation drug, was approved to use heart failure treatment recently. There are limited studies on the relationship between sacubitril/valsartan and left ventricular contraction. In our study, we aimed to evaluate the changes in left ventricular ejection fraction insert ignore into journalissuearticles values(LVEF); after sacubitril/valsartan treatment. Patients and Methods: Fifty-two patients with heart failure and reduced ejection fraction insert ignore into journalissuearticles values(HFrEF); were enrolled in this study. The baseline demographic, clinical, and echocardiographic characteristics of 52 patients were compared using the Bayesian method. Results: Fifty-two patients with heart failure and reduced ejection fraction insert ignore into journalissuearticles values(HFrEF); were included in the final analysis insert ignore into journalissuearticles values(66.2 ± 9.3 years, 69.2% male);. Sacubitril/valsartan initial dose was low in 44.2% of patients, and intermediate in 55.8%. In the low initial dose population, the increase in absolute LVEF was 3.87 insert ignore into journalissuearticles values(95% HDI 1.53-6.20); and in the intermediate initial dose population, the increase in absolute LVEF was 5.89 insert ignore into journalissuearticles values(95% HDI 4.18-7.61);. In the female population, the increase in absolute LVEF was 5.56 insert ignore into journalissuearticles values(95% HDI 3.49-7.63); and in the male population 4.75 insert ignore into journalissuearticles values(95% HDI 2.91-6.58); respectively. Conclusion: In this study, we demonstrated that sacubitril/valsartan is associated with increased LVEF regardless of baseline clinical characteristics.
Keywords : ARNI, bayesian, ejection fraction