Association Between Systemic ImmuneInflammation Index and Long-Term Mortality in Patients with Critical Limb-Threatening Ischemia Undergoing Endovascular Therapy Below the Knee

Authors : Yalçın AVCI, Mustafa DURAN, Ali Rıza DEMİR, Gökhan DEMİRCİ, Ömer TAŞBULAK, Arda GÜLER, Ahmet Arif YALÇIN, Sezgin ATMACA, Mehmet ERTÜRK

Pages : 262-269

View : 16 | Download : 7

Publication Date : 2022-12-01

Article Type : Research Paper

Abstract :Introduction: Endovascular interventions have been increasingly used for the treatment of patients suffering from below-the-knee insert ignore into journalissuearticles values(BTK); ischemic lesions. Yet, there is a paucity of data regarding long-term adverse events in patients with critical limb ischemia insert ignore into journalissuearticles values(CLI); undergoing endovascular revascularization for BTK lesions. Recently introduced systemic immune-inflammation index insert ignore into journalissuearticles values(SII); is a reliable indicator of poor outcomes in various cardiovascular conditions. Herein, we aimed to investigate the prognostic role of the SII on mortality in patients with CLI undergoing endovascular revascularization for BTK lesions. Patients and Methods: The records of 112 patients with symptomatic CLI undergoing endovascular revascularization for BTK lesions between January 2015 and December 2019 were analyzed. Patients were divided into groups with low and high SII values based on an SII cut-off value derived from a ROC analysis. For each group, procedural details and follow-up outcomes were analyzed. Results: The mean follow-up time was 40.3 ± 19.9 months. According to our data, patients with high SII values had higher rates of mortality compared to patients with low SII values insert ignore into journalissuearticles values(65.2% vs 30.3%, p< 0.001);. To determine the SII cut-off value for predicting mortality, the ROC curve was drawn, and the best cut-off value was determined as 966 by using the Youden index, insert ignore into journalissuearticles values(AUC= 0.658, 95% CI= 0.556-0.760, p= 0.004);. Cox multivariate regression analysis also identified the SII score as an independent predictor of mortality. Conclusion: SII is an independent predictor of mortality, especially among patients with CLI who underwent endovascular revascularization for BTK lesions.
Keywords : Endovascular procedures, inflammation, peripheral arterial disease, peripheral arterial disease