Quaercetin Improves Renal Functional Disorder and Dyslipidemia Caused by Acute Cadmium Exposure

Authors : Durmuş HATİPOĞLU, Mehmet ÖZSAN, İhsan KISADERE, Nurcan DÖNMEZ

Pages : 50-58

Doi:10.53518/mjavl.1196166

View : 44 | Download : 58

Publication Date : 2023-07-01

Article Type : Research Paper

Abstract :Heavy metal toxicity and bioaccumulation caused severe damage to soil, water and environment as a result of industrialization/urbanization activities in developing and developed countries. This damage has affected different trophic levels including plants, animals and humans and has become a global concern. The use of various phytonutrients such as Quercetin insert ignore into journalissuearticles values(QE); has increased in recent years to avoid toxicity caused by heavy metals. Among different heavy metals, cadmium insert ignore into journalissuearticles values(Cd); toxicity is a major issue in the countries. Cd is a toxic heavy metal that can damage the kidneys and cause dysregulation in many lipid metabolic pathways. However, the number of studies on renal dysfunction and dyslipidemia caused by Cd is limited. We found that Cd causes renal dysfunction and dyslipidemia, and QE ameliorates these Cd-induced damages. Our results showed that Cd increased urea, uric acid, creatnine, alkene phosphatase insert ignore into journalissuearticles values(ALP);, total bilirubin insert ignore into journalissuearticles values(TBIL); levels compared to the control group, while QE improved other parameters except TBIL. In addition, our findings showed that Cd increased total glyceride insert ignore into journalissuearticles values(TG);, total cholesterol insert ignore into journalissuearticles values(TC);, low-density lipoprotein insert ignore into journalissuearticles values(LDL); and lactate dehydrogenase insert ignore into journalissuearticles values(LDH); levels and decreased high-density lipoprotein insert ignore into journalissuearticles values(HDL); levels. It was noted that QE tended to improve this dyslipidemia picture. The data presented here demonstrated that QE has a clear protective role against dyslipidemia and renal function against Cd toxicity through its hypolipidemic and antioxidative action.
Keywords : Cadmium, Kidney Functions, Dyslipidemia