Erythrocyte susceptıbılıty to lıpıd peroxıdatıon and antıoxıdant system ın parkınson’s dısease patıents

Authors : A. Kilinç, A.S. Yalgn, Y. Taga, K. Emerk, D. Yalçin

Pages : 6-8

View : 7 | Download : 5

Publication Date : 1988-01-01

Article Type : Research Paper

Abstract :It has been suggested that among the factors that lead to neuron loss in substantia nigra in Parkinson`s disease are stimulation of lipid peroxidation and deficiency of glutathione and glutathione peroxidase. In this study, the effect of neurodegenerative changes on plasma and erythrocytes were investigated in Parkinson`s disease. The results were compared with age-matched controls. Increase in plasma lipid peroxide levels and erythrocyte susceptibility to lipid peroxidation were observed in patients with Parkinson`s disease. Erythrocyte catalase activities were not changed whereas glutathione levels and glutathione peroxidase activities were decreased. Our results suggest that erythrocyte membrane integrity is impaired in Parkinson`s disease. We are carrying out more detailed studies to determine whether this is related to neurodegenerative changes observed in Parkinson’s disease and whether parkinsonians will benefit from antioxidant treatment.
Keywords : Antioxidant system, Plasma, Erythrocyte, Lipid peroxidation, Parkinsons disease