The relaxant effect of ketamine in isolated rabbit aortic strips

Authors : Y. SARIOĞLU, T. UTKAN, S. SOYDAN, T. KAYA

Pages : 138-141

View : 13 | Download : 5

Publication Date : 1992-12-01

Article Type : Research Paper

Abstract :This study was undertaken to determine whether ketamine can exert any action on basal endothelium derived relaxing factor insert ignore into journalissuearticles values(s); release and vasodilator effect of acetylcholine on phenylephrine induced contractile responses in isolated rabbit aortic strips. Ketamine did not induce any contractile response in the aortic strips at various concentrations insert ignore into journalissuearticles values( 1to 10`3 M);. Ketamine did not significantly alter phenylephrine-induced contractions at lower concentrations insert ignore into journalissuearticles values(10`8 to 10‘5 M);, but at higher concentrations insert ignore into journalissuearticles values(10‘4 to 10`3 M); the depression caused by ketamine was significant in both endothelium intact and denuded strips. Propranolol, methysergide, atropine, diphenhydramine and indomethacine did not block the relaxant effect of ketamine. Pretreatment of the endothelium intact strips with ketamine insert ignore into journalissuearticles values(10`5 M); had no effect on the relaxant effect of acetylcholine which was observed on endothelium intact aortic strips. The relaxant effect of ketamine on the isolated rabbit aortic strips does not seem to interact with the changes in the release of EDRF from endothelial cells.
Keywords : Ketamine, EDRF, Rabbit Aorta