Effects of diltiazem on renal function

Authors : S. TOPÇU, S. SAĞIR, F. CANDAN, S. İÇAĞASIOĞLU, C. YILDIRIR

Pages : 11-14

View : 9 | Download : 9

Publication Date : 1995-01-01

Article Type : Research Paper

Abstract :We planned to investigate the effect of diltiazem on urine volume, urine sodium insert ignore into journalissuearticles values(Na+); and potassium insert ignore into journalissuearticles values(K+); excretion and glomerular filtration rate insert ignore into journalissuearticles values(GFR);. Twenty healthy men, aged between 23 and 36 insert ignore into journalissuearticles values(mean age: 29 ± 0.87); were examined. A double - blind placebo controlled study was completed by weekly intervals in 3 periods. In each period, first day no drug was given, the second day placebo, the third day diltiazem insert ignore into journalissuearticles values(30 mg or 60 mg); or placebo was given. In the first 6 hour period following diltiazem 30 or 60 mg administration, increases in GFR insert ignore into journalissuearticles values(p<0.05);, urine volume insert ignore into journalissuearticles values(p<0.01); and urine Na+ excretion were significant insert ignore into journalissuearticles values(p<0.001);, but increase in urine K+ excretion was not significant insert ignore into journalissuearticles values(p>0.05);. In the next 18 hour period, we observed that diltiazem did not affect the excretion of K+ urine volume and GFR insert ignore into journalissuearticles values(p> 0.05);, but increased the excretion of Na+ insert ignore into journalissuearticles values(p<0.05);.
Keywords : Diltiazem, GFR, Natriuretic, Diuretic effect