Estrogen modulating effects of resveratrol in female rats

Authors : Fikriye Yasemin ÖZATİK, Kevser EROL, Orhan ÖZATİK

Pages : 95-101

Doi:10.5472/MMJoa.2902.06

View : 17 | Download : 4

Publication Date : 2016-04-01

Article Type : Research Paper

Abstract :Objectives: This study investigates the estrogen-like effects of resveratrol insert ignore into journalissuearticles values(RES); in female rats.Materials and Methods: In this two-step study on estrogenlike activity of RES, immature female rats insert ignore into journalissuearticles values(21 days old); were used in the first step and pubertal female rats insert ignore into journalissuearticles values(28 days old); with primary ovarian failure insert ignore into journalissuearticles values(POF); induced by 4-vinylcyclohexene diepoxide insert ignore into journalissuearticles values(VCD); were used in the second step. Possible agonistic and/or antagonistic effects of RES were investigated by using several parameters including the ratios of uterine/body weights insert ignore into journalissuearticles values(UBW);, uterine dry/wet weights insert ignore into journalissuearticles values(UDWW); and body weight increase insert ignore into journalissuearticles values(BW%);, bone density measurement, serum estradiol and vitamin D levels and histological evaluation.Results: In immature rats, RES resulted in an increase in UBW equal to that produced by 17 alpha-ethinyl estradiol insert ignore into journalissuearticles values(17alphaEE);. The minimum effective dose for RES was 10 mg/kg. This effect was not decreased by tamoxifen but was significantly antagonized by fulvestrant. Similarly, tamoxifen did not abolish the effects ofRES completely in rats with POF. However, in rats with VCDinduced POF, tamoxifen resulted in lower UBW values and estradiol levels were significantly higher in 17alphaEE-treated, RES+tamoxifen-treated and 17 beta-estradiol insert ignore into journalissuearticles values(17betaE);-treated rats compared to control animals.Conclusion: The dose of RES may be important in terms of estrogenic activity and even RES may modulate the effects of estrogen.Keywords: Estrogen, Resveratrol, 4-vinylcyclohexene diepoxide, Primary ovarian failure
Keywords : Estrojen, Resveratrol, 4 vinilsikloheksen diepoksid, Primer over yetmezliği