Antinociceptive effects of morphine and physostigmine in different inbred strains of mice

Authors : A.n. ASLAN, K. BERKMAN, B. ÇIRAKOĞLU, Ş. OKTAY

Pages : 7-10

View : 11 | Download : 2

Publication Date : 1996-01-01

Article Type : Research Paper

Abstract :Antinociceptive effects of morphine and physostigmine, alone or in combination were investigated in mice of BALB/C, C57BL/6 and CB6F1 strains. Morphine and physostigmine increased pain treshold in BALB/C and CB6F1 mice at a dose of 5 mg/kg and 0.1 mg/kg, respectively, whereas C57BL/6 mice were found to be less responsive to both agents. When a nonanalgesic dose of physostigmine insert ignore into journalissuearticles values(0.05 mg/kg); was combined with a nonanalgesic dose of morphine insert ignore into journalissuearticles values(2.5 mg/kg);, a significant antinociceptive effect was observed in BALB/C and CB6F1 mice, but not in C57BL/6 strain. These results suggest that there is a significant influence of strain on cholinergic and opioid antinociception, and synergistic interaction between cholinergic and opioidergic systems also occur strain-dependently.
Keywords : Analgesia, tail flick, morphine, physostigmine, BALB C, C57BL76, CB6F1