EFFECT OF BETTER CONTROL OF HYPERTENSION ON LEFT VENTRICULAR MASS IN LONG TERM RENAL TRANSPLANT RECIPIENTS

Authors : Mehmet Koç, Ahmet Toprak, Hakan Tezcan, Serhan Tuğlular, İshak Çetin Özener, Emel Akoğlu

Pages : 173-178

View : 15 | Download : 5

Publication Date : 2016-12-03

Article Type : Research Paper

Abstract :Objective: Control of hypertension insert ignore into journalissuearticles values(HT); can lead to regression of left ventricular mass index insert ignore into journalissuearticles values(LVMI); especially in the first year of renal transplantation. However, effect of better control of blood pressure insert ignore into journalissuearticles values(BP); on regression of LVMI in long-term renal transplant recipients is not known. In this study, we aimed to determine whether improved control of HT would decrease LVMI in renal transplant recipients or not. Methods: Twenty-four nondiabetic renal transplant recipients were included in the final analysis. Patients were categorized into group A insert ignore into journalissuearticles values(controlled-HT); and group B insert ignore into journalissuearticles values(uncontrolled-HT); according to their daytime blood pressure levels at the beginning of the study. Antihypertensive drug treatment of patients in group B was modified according to ambulatory blood pressure monitorization insert ignore into journalissuearticles values(ABPM); and clinical measurements. Echocardiographic examination was performed at baseline and at the end of 24 month. Results: Systolic blood pressure insert ignore into journalissuearticles values(SBP); and diastolic blood pressure insert ignore into journalissuearticles values(DBP); declined significantly insert ignore into journalissuearticles values(p<0.01); in parallel to increased use of angiotensin converting enzyme inhibitor insert ignore into journalissuearticles values(p<0.01); and LVMI remained unchanged in group B insert ignore into journalissuearticles values(113 ± 34 g / m2 vs 112 ± 29 g / m2 at baseline and at the end of 24 month, respectively);. Although SBP and DBP did not change significantly in group A, LVMI increased significantly insert ignore into journalissuearticles values(90 ±21 g / m2 to 107 ± 26 g / m2 at baseline and at the end of 24 month, respectively); in parallel to increase in serum creatinine insert ignore into journalissuearticles values(p<0.05); and decline in hemoglobin levels. Conclusions: Our results suggest that control of BP is not sufficient either for the regression or maintenance of LVMI in long term renal transplant recipients. However, factors such as low hemoglobin level and worsening of renal function may play critical roles in the progression of LVMI even in patients with well-controlled BP. Key Words: Renal transplantation, Left ventricular hypertrophy, Hypertension, Ambulatory blood pressure monitoring
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