Outcomes and clinical features of leptomeningeal carcinomatosis: A single center experience

Authors : Derya KIVRAK SALIM, Arif Hakan ONDER

Pages : 81-85

Doi:10.5472/marumj.570913

View : 8 | Download : 4

Publication Date : 2019-05-31

Article Type : Research Paper

Abstract :Objective: The aim of this study was to identify the clinical features and prognostic factors of cancer patients with leptomeningeal carcinomatosis insert ignore into journalissuearticles values(LMC); in a single center. Patients and Methods: Patients 18 and older who had LMC diagnosis between 2013 and 2018 at Medical Oncology Department, Antalya Education and Research Hospital, Health Sciences University were included into the study. Their clinical features, treatment approaches, overall survival, survival after LMC diagnosis and prognostic factors on survival were retrospectively investigated. Results: Sixteen solid cancer patients included in the study. The median time from primary tumor diagnosis to LMC diagnosis was 6 months insert ignore into journalissuearticles values(range, 1-180 months);. The median time from LMC diagnosis to death was 1.5 months insert ignore into journalissuearticles values(range, 1-14 months);. The median overall survival for the entire population was 11 months insert ignore into journalissuearticles values(95%CI 5.7-16.3);. Age insert ignore into journalissuearticles values(p=0.6);, gender insert ignore into journalissuearticles values(p=0.51);, metastases areas insert ignore into journalissuearticles values(for liver metastases p=0.95, for lung metastases p=0.26, for bone metastases p=0.82);, The Eastern Cooperative Oncology Group Performance Status insert ignore into journalissuearticles values( ECOG PS); insert ignore into journalissuearticles values(p=0.18);, treatment type of LMC insert ignore into journalissuearticles values(only radiation therapy insert ignore into journalissuearticles values(RT); p=0.33; RT followed by intrathecal methotrexate insert ignore into journalissuearticles values(IT MTX); insert ignore into journalissuearticles values(p=0.35);, RT type insert ignore into journalissuearticles values(p=0.76); and time from primary tumor diagnosis to LMC diagnosis insert ignore into journalissuearticles values(p=0.50); did not show prognostic effect on overall survival after LMC diagnosis. Conclusion: Overall survival after LMC diagnosis is too short to see the effect of treatment modalities. Our study did not find any favorable or unfavorable prognostic factor on survival after LMC diagnosis.
Keywords : Leptomeningeal carcinomatosis, Survival, Prognostic factors