The role of diffusion tensor imaging for the assessment of liver fibrosis and inflammation in chronic viral hepatitis: A preliminary study

Authors : Ozge YAPICI UGURLAR, Mehmet Sait BUGDAYCI, Abdullah Soydan MAHMUTOGLU, Canan ALKIM, Banu YILMAZ OZGUVEN, Alper OZEL, Muzaffer BASAK, Yasin AYKUT, Huseyin OZKURT, Sukru Mehmet ERTURK

Pages : 97-101

Doi:10.5472/marumj.741724

View : 13 | Download : 4

Publication Date : 2020-05-31

Article Type : Research Paper

Abstract :Objective: To evaluate the role of magnetic resonance insert ignore into journalissuearticles values(MR); diffusion tensor imaging insert ignore into journalissuearticles values(DTI); in the assessment of liver fibrosis and inflammation in chronic viral hepatitis by measuring apparent diffusion coefficient insert ignore into journalissuearticles values(ADC); and fractional anisotropy insert ignore into journalissuearticles values(Fa); values. Material and Methods: Twenty-seven patients insert ignore into journalissuearticles values(5 women and 22 men;mean age39.8±11.3); with hepatic fibrosis were included in our study. The relationship between ADC, Fa values and histological activity index insert ignore into journalissuearticles values(HAI); score were evaluated using Spearman’s correlation coefficient. Patients were subgrouped as group A insert ignore into journalissuearticles values(fibrosis score 1); and group B insert ignore into journalissuearticles values(fibrosis score 3);. The mean ADC and Fa values of groups A and B were compared using Student’s t-test. To evaluate the use of ADC and Fa values in distinguishing group A from group B, ROC analysis was applied; sensitivities and specificities were calculated. Results: Fa values correlated with HAI scores significantly insert ignore into journalissuearticles values(r=0.397, p<0.05); The difference was significant between the mean ADC values insert ignore into journalissuearticles values(group A:1.46± 0.191x103mm2/s; group B:1.105± 0.141x10-3 mm2/s; p<0.001); and Fa values insert ignore into journalissuearticles values(group A: 0.473±0.091; group B: 0.643± 0.007; p<0.001); between the groups. For distinguishing group A from group B, ADC had a sensitivity of 81.8% and a specificity of 93.8%. The sensitivity and specificity of Fa were 90.9% and 100%, respectively. Conclusion: Diffusion tensor imaging may play a role in the evaluation of fibrosis and HAI scores in patients with liver fibrosis.
Keywords : Hepatitis, Liver fibrosis, Diffusion tensor imaging