p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis

Authors : Meltem KOLGAZI, Gulsen OZTOSUN, Muge YALCIN, Zehra Neslisah UNAN, Edanur ARSOY, Simge ORAL, Sumeyye CILINGIR, Merve ACIKEL ELMAS, Serap ARBAK

Pages : 6-11

Doi:10.5472/marumj.859006

View : 11 | Download : 4

Publication Date : 2021-01-29

Article Type : Research Paper

Abstract :Objective: p-Coumaric acid is commonly found in edible plants in nature and is known to be an effective antioxidant. This study aimed to investigate the therapeutic effects of p-coumaric acid on ethanol-induced gastric ulcer model Materials and Methods: After an 18-hour starvation period, the ulcer was induced in male Sprague-Dawley insert ignore into journalissuearticles values(250-300); rats by intragastric administration of 75% ethanol. An hour after ulcer induction, p-coumaric acid insert ignore into journalissuearticles values(250 mg/kg); suspended in 1 ml tween-80 was administered intragastrically. The control and ulcer groups received 1 ml tween-80. One hour later, all rats were euthanized and stomach samples were collected for macroscopic examination, histological evaluation, and measurement of myeloperoxidase insert ignore into journalissuearticles values(MPO); activity, malondialdehyde insert ignore into journalissuearticles values(MDA);, and glutathione insert ignore into journalissuearticles values(GSH); levels. Results: Ethanol induction resulted in gastric epithelial and mucosal injury, increased MPO activity and MDA levels; and decreased GSH levels. Treatment with p-coumaric acid at a dose of 250 mg/kg markedly improved the gastric injury macroscopically, microscopically, and biochemically due to decreasing MPO activity and MDA levels while increasing GSH levels. Conclusion: p-Coumaric acid markedly ameliorated the gastric epithelial and mucosal injury induced by ethanol. The therapeutic effects of p-coumaric acid could be due to its antioxidant properties and protective role against GSH depletion and neutrophil accumulation.
Keywords : p Coumaric acid, Ulcer, Ethanol, Antioxidant, Neutrophil