Does methylprednisolone affect time to recovery in COVID–19 Pneumonia?

Authors : Derya KOCAKAYA, Şehnaz OLGUN YILDIZELI, Baran BALCAN, Emel ERYUKSEL, Sait KARAKURT

Pages : 120-126

Doi:10.5472/marumj.942800

View : 14 | Download : 5

Publication Date : 2021-05-31

Article Type : Research Paper

Abstract :Objective: Current literature has conflicting results on the role of steroids in the treatment of coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); pneumonia. This study aims to evaluate the effects of steroids on clinical recovery, duration of hospitalization, and time needed for the cessation of oxygen treatment. Patients and Methods: We retrospectively analyzed the medical records of patients hospitalized for COVID-19 between March and May 2020. Patient age, laboratory parameters, clinical stages, radiologic scores, length of hospital stay, and time needed for the cessation of oxygen supplementation were compared. Results: Thirteen patients were treated with steroids, and 12 controls were included in the analysis. Regarding the laboratory parameters, the groups were similar except for lymphocyte percentage insert ignore into journalissuearticles values(9.8 ± 3.2, 7.0 ± 2.9; p=0.033);, which was higher, and D-dimer levels insert ignore into journalissuearticles values(0.75 insert ignore into journalissuearticles values(0.60-1.43);, 1.57 insert ignore into journalissuearticles values(0.91-2.29);; p=0.047);, which were lower in the steroid group on admission. Steroid treatment provided a tendency of decrease in time to cessation of oxygen supplementation insert ignore into journalissuearticles values(6.23 ± 3.4 vs 7.67 ± 2.1, p=0.217);. Conclusion: Although, systemic steroids, started in the subacute period, did not affect the length of hospital stay, they provided a tendency of decrease in the time until the cessation of oxygen supplementation in the subacute period.
Keywords : COVID 19, Steroids, Length of stay