The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

Authors : Emrah KESKIN, Ozlem ELMAS, Havva Hande KESER SAHIN, Caghan TONGE, Ahmet GUNAYDIN

Pages : 211-218

Doi:10.5472/marumj.1121375

View : 14 | Download : 6

Publication Date : 2022-05-30

Article Type : Research Paper

Abstract :Objective: This study aimed to evaluate Annona muricata’s insert ignore into journalissuearticles values(AM); radioprotective effects on sciatic nerve injury due to ionising radiation insert ignore into journalissuearticles values(IR);. Materials and Methods: Thirty-two adult female Wistar albino rats were separated into four equal groups; Control insert ignore into journalissuearticles values(C);, Annona muricata leaf extracts insert ignore into journalissuearticles values(AME);, radiation insert ignore into journalissuearticles values(RAD);, radiation and AME insert ignore into journalissuearticles values(AME+RAD);. In groups AME and AME+RAD, AME was administered at a dose of 300 mg/kg for the first day and 50 mg/every day for the following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray insert ignore into journalissuearticles values(Gy); IR to their right legs. All the subjects were sacrificed at the end of the first month. Oxidative stress biochemical parameters from blood samples were analysed. In addition, right sciatic nerves were extracted and histomorphology was evaluated. Results: Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME insert ignore into journalissuearticles values(p<0.01);. Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of catalase insert ignore into journalissuearticles values(p<0.01);, superoxide dismutase insert ignore into journalissuearticles values(p<0.01); and glutathione peroxidase insert ignore into journalissuearticles values(p<0.05); in the AME+RAD group compared to the RAD group were found to be statistically significant. Conclusion: Our study unveiled that AM could potentially enhance biochemical and histomorphological healing in the acute period on sciatic nerve injury due to IR.
Keywords : Radiation, Sciatic nerve, Annona muricata, Neuroprotection, Oxidative stress