The relationship between renal functions and multi-drug resistant organisms in patients with ventilator-associated pneumonia

Authors : Omur ILBAN, Aysegul ILBAN

Pages : 52-58

Doi:10.5472/marumj.1244732

View : 8 | Download : 3

Publication Date : 2023-01-31

Article Type : Research Paper

Abstract :Objective: Despite the increase in the frequency of multi-drug resistant organism insert ignore into journalissuearticles values(MDRO); colonisation and infection in dialysis patients, it is not well known whether the risk of multi-drug resistant insert ignore into journalissuearticles values(MDR); pneumonia increases in mild-to-severe chronic kidney disease patients not undergoing dialysis. Therefore, we aimed to evaluate the relationship between renal functions and the risk of MDR ventilator-associated pneumonia insert ignore into journalissuearticles values(VAP); and the specific microbial pattern. Patients and Methods: A total of 133 patients who developed VAP were divided according to their renal function into two groups, an estimated glomerular filtration rate of insert ignore into journalissuearticles values(eGFR); ≥ 60 mL/ min/1.73 m2 insert ignore into journalissuearticles values(high eGFR, n=65); and eGFR < 60 mL/min/1.73 m2 insert ignore into journalissuearticles values(low eGFR, n=68);. Results: The low eGFR group presented a significantly high MDRO ratio insert ignore into journalissuearticles values(p<0.01);. With the decrease in eGFR, the frequency of grampositive MDRO did not change insert ignore into journalissuearticles values(p=0.63);, while the increase in gram-negative MDRO was statistically significant insert ignore into journalissuearticles values(p<0.01);. Low eGFR was found to be an independent predictor for antimicrobial resistance. insert ignore into journalissuearticles values(Odds ratio, insert ignore into journalissuearticles values(OR);: 2.821);. Conclusion: Among VAP patients, chronic renal failure is associated with increased MDRO infection. The eGFR may be used to identify mechanically ventilated patients with a high risk of MDR pneumonia.
Keywords : Chronic kidney disease, Glomerular filtration rate, Multiple drug resistance, Risk factors, Ventilator associated pneumonia