Predictors of outcomes in patients with candidemia in an Intensive Care Unit

Authors : Ayşe Serra ÖZEL, Lütfiye Nilsun ALTUNAL, Buket Erturk SENGEL, Muge ASLAN, Mehtap AYDIN

Pages : 284-289

Doi:10.5472/marumj.1367454

View : 25 | Download : 47

Publication Date : 2023-09-29

Article Type : Research Paper

Abstract :Objective: Candidemia is a life-threatening infection that causes high mortality rates in intensive care units insert ignore into journalissuearticles values(ICUs);. This study aims to evaluate predictors of the outcome of patients with candidemia in ICU. Patients and Methods: This observational, retrospective study included patients with Candida bloodstream infection insert ignore into journalissuearticles values(BSI); in ICUs between 6 years of the episode. A binary logistic regression analysis was conducted to inspect the association with mortality. Results: The median age of 74 patients was 68.5, and 53.8% were men. C. parapsilosis was the most frequently isolated fungal species. The 30-day mortality rate was 50%. In the logistic regression model the Acute Physiology and Chronic Health Evaluation insert ignore into journalissuearticles values(APACHE); II score, positive blood culture on the seventh day, inotropes needed on the day of blood culture positivity, and ventilator-associated pneumonia insert ignore into journalissuearticles values(VAP); were significant risk factors for the outcome of patients. There was no difference in mortality between an early start of antifungal treatment or central venous catheter removal time. Conclusion: A shift to C. parapsilosis is observed in this study. Host-related factors such as APACHE II score, need for mechanical ventilation or need for inotropes affect mortality more than early treatment and source control in patients with Candida BSI.
Keywords : Candida, Candidemia, Intensive Care Unit, Mortality, Outcome