Diagnostic utility of the systemic immune-inflammatory index in preterm neonates with late-onset sepsis

Authors : Gonca VARDAR, Eren ÖZEK

Pages : 319-325

Doi:10.5472/marumj.1367904

View : 14 | Download : 34

Publication Date : 2023-09-29

Article Type : Research Paper

Abstract :Objective: To assess if systemic immune-inflammatory index insert ignore into journalissuearticles values(SII); has a diagnostic role for late-onset sepsis insert ignore into journalissuearticles values(LOS); in premature neonates. Patients and Methods: A single-center retrospective observational study including preterm infants with culture-proven LOS and controls was conducted between January 2017 and December 2022. SII was derived using complete blood count values acquired at the beginning of and three to five days before LOS. SII was compared between the LOS group and controls. Results: A total of 144 infants were included in the study. The SII values of the LOS group were found to be significantly increased in comparison to the control group [376.74 insert ignore into journalissuearticles values(11.11 – 15170); vs. 235.24 insert ignore into journalissuearticles values(46.83 – 1214.38); insert ignore into journalissuearticles values(median, min-max);, P =0.018]. The SII values significantly increased when pre-sepsis and LOS values were compared [200.6 insert ignore into journalissuearticles values(0 – 1295.78); vs. 328.28 insert ignore into journalissuearticles values(0 – 14678, P<0.001]. As determined using the receiver operating characteristic analysis, the area under the curve for SII was 0.621 insert ignore into journalissuearticles values(44.4% sensitivity, 83.3% specificity, 72.7% positive predictive value, and 60% negative predictive value); for predicting LOS. Conclusion: Although, further research is required, SII may be used with other biomarkers to identify LOS in preterm infants and may constitute a readily accessible additional diagnostic parameter.
Keywords : Late onset sepsis, Systemic immune inflammatory index, Neonate, Biomarker