Evaluation of the Relationship Between Cervical Intraepithelial Neoplasia Grades and Connexin 43

Authors : Havva ERDEM, Mürüvvet AKÇAY ÇELİK

Pages : 15-19

Doi:10.19127/mbsjohs.332613

View : 14 | Download : 12

Publication Date : 2017-12-28

Article Type : Research Paper

Abstract :Objective: Cervical intraepithelial neoplasia insert ignore into journalissuearticles values(CIN); is a premalign cervical disease. The microscopic features of CIN indicates an alteration leading to dedifferentiation and loss of maturation in the squamous epithelium. Disruption of connexins are frequently reported in malignant cell lines. Here, it is aimed to show the relationship between the dysplasia grades and connexin. Methods: 79 cases were included in the study who were referred to the pathology department between 2014 and 2015 and who had CIN insert ignore into journalissuearticles values(grade 1, 2, 3);. Sections of 3 micrometer thickness were taken from the paraffin blocks of the uterus on the polylysine slide. Cx43 antibody with ABC tecnique were performed to these sections. Staining cells were defined as positive. The cases were graded according to the intensity of the staining. Results: The distribution of 79 dysplastic cases was as follows. 41 of these cases had CIN 1. The average age of these women was 44.93. 16 women were diagnosed with CIN2. The average age of these women was 42.06. 22 women were diagnosed with CIN 3. The average age of the women was 48.87. Conclusion: In this study, complete loss of Cx43 expression was observed in all dysplastic cervical cases.
Keywords : Cervical intraepithelial neoplasia, degree of dysplasia, Cx43