Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

Authors : Tuğba CEBECİ, Dilek KESKİN, Ahmet Ali GÖKAL

Pages : 33-38

Doi:10.19127/mbsjohs.525833

View : 15 | Download : 5

Publication Date : 2019-04-28

Article Type : Research Paper

Abstract :Objective : A retrospective analysis of the widely used antibiotics all susceptibility testing results from Escherichia coli insert ignore into journalissuearticles values( E. coli ); cultured from clinical specimens private hospital insert ignore into journalissuearticles values(from January 2017 to November 2018 ); was performed.   Methods: The VITEK 2 Compact automated microbiology system insert ignore into journalissuearticles values(bioMérieux); is designed for automated rapid antimicrobial susceptibility testing and identification of clinically relevant bacteria. Minimum inhibitory concentration insert ignore into journalissuearticles values(MIC); results previously obtained in recent clinical isolates with well-defined in isolates with well-characterized resistance mechanisms with the microdilution method were re-interpreted for the susceptible, intermediate and resistant categories using the 2018 EUCAST breakpoints. Clinical samples are most commonly isolated from blood, sputum and urine samples.   Results: The results of resistance pattern of E. coli isolates in our locality to antimicrobial agents showed that the 64 E. coli strains tested against fifteen antimicrobial agents. E. coli isolates were highly resistant to piperacillin, ceftazidime and aztreonam 98%, 61% and 61% respectively. The most sensitive antibiotics were colistin, tigecycline, imipenem and meropenem. In the present study, 73% insert ignore into journalissuearticles values(47); of the isolates were resistant to at least three to fourteen antibiotics. All of the isolates showed resistance to at least one antibiotics. Thirty nine per cent of E. coli isolates were extended spectrum beta-lactamase insert ignore into journalissuearticles values(ESBL); producers.   Conclusion: Considering the antibiogram, imipenem and meropenem should be preferred drugs for E. coli infection isolated from clinical samples.
Keywords : Esherichia coli, antibiotic sensitivity, clinical specimens, intensive care unit