Antimicrobial Susceptibility Profiles and Prevalence of ESBLS among Escherichia coli Isolates Recovered from Clinical Specimens in Different Services

Authors : Tuğba CEBECİ, Dilek KESKİN, Ahmet Ali GÖKAL

Pages : 186-191

Doi:10.19127/mbsjohs.570826

View : 16 | Download : 6

Publication Date : 2019-12-31

Article Type : Research Paper

Abstract :Objective: A retrospective analysis of the widely used antibiotics all susceptibility testing results from Escherichia coli cultured from clinical specimens private hospital from insert ignore into journalissuearticles values(January 2016 to November 2018); was performed. Methods: The VITEK 2 Compact automated microbiology system is designed for automated rapid antimicrobial susceptibility testing and identification of clinically relevant bacteria. Minimum inhibitory concentration insert ignore into journalissuearticles values(MIC); results previously obtained in recent clinical isolates with well-defined in isolates with well-characterized resistance mechanisms with the microdilution method were re-interpreted for the susceptible, intermediate and resistant categories using the 2018 EUCAST breakpoints. Clinical samples are most commonly isolated from blood, sputum and urine samples. Results: Escherichia coli isolates were highly resistant to ampicillin, cefuroxime and cefixime 79,16%, 60,41% and 58,33% respectively. Resistance rate of ceftriaxon was showed in 52,08%. When we compared to resistance of trimethoprim/sulfamethoxazole, Escherichia coli isolates showed 51,04% resistance rate. When it comes to the most sensitive antibiotics, sensitivity rate of fosfomycin, nitrofurantoin, ertapenem, imipenem, meropenem, gentamicin, and amikacin were 89,58%; 91,66%; 93,75%; 93,75%; 94,79%; 83,33%; 84,37% respectively. Conclusion: Considering the antibiogram, fosfomycin, nitrofurantoin, ertapenem, imipenem, meropenem, gentamicin and amikacin should be preferred drugs for E. coli infection isolated from clinical samples.
Keywords : E coli, antibiotic sensitivity, clinical specimens