Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder

Authors : İlkay BAHÇECİ, Umut Serkan SÖZTANACI, Meltem PUŞUROĞLU, Nuray ARSLAN, Ömer Faruk DURAN, Bulent BAHCECİ, Zihni Acar YAZICI

Pages : 397-403

Doi:10.19127/mbsjohs.1024605

View : 21 | Download : 6

Publication Date : 2021-12-31

Article Type : Research Paper

Abstract :Objective: The aim of this study was to evaluate the relationship between apelin-36 and oxidative parameters and Generalized Anxiety Disorder insert ignore into journalissuearticles values(GAD);. Apelin which prevents hippocampal neuronal death is an endogenous ligand for G protein bound APJ receptors in the central nervous system. Oxidative Stress were occurred by free radicals which caused apoptosis in the hypothlamus, hippocampus and amygdala regions of the Central Nervous System insert ignore into journalissuearticles values(CNS);. Methods: In this study, 61 patients diagnosed generalized anxiety disorder at psychiatry polyclinic and 55 control subjects were enrolled. The Structured Clinical Interview for DSM-IV Axis I Disorders insert ignore into journalissuearticles values(SCID-I); and the Hamilton Anxiety Rating Scale insert ignore into journalissuearticles values(HARS); were used in this study and they were filled by the patients and healthy individuals. Serum apelin-36 level was measured by using an ELISA kit. Total antioxidant status insert ignore into journalissuearticles values(TAS); and Total Oxidant Status insert ignore into journalissuearticles values(TOS); in the serum was measured by an automated system. The data were analyzed by using the SPSS. Results: It was found that serum apelin-36, TOS and Oxidative stress index insert ignore into journalissuearticles values(OSI); levels were significantly lower in patients’ group than controls. In addition, negative correlation was detected between apelin 36 levels and HARS scores, TOS and OSI values in patients’ group. TAS values were found as similar between the patient and control group. There was no correlation between TAS and Apelin 36 in the patient group. Conclusion: In this study it was found that serum apelin-36, TOS and OSI levels were low in GAD. According to the results, Apelin-36 and oxidative stress may play a role in the etiopathogenesis of Generalized Anxiety Disorder.
Keywords : Apelin 36, , General Anxiety Disorder, , Oxidative stress, , Total antioxidant status, , total oxidant status