The Role of Hypericum Perforatum (St. John`s Wort Oil) and Olive Oil in the Prevention of Peritoneal Adhesion in a Rat Model: An Animal Study

Authors : Tuğrul KESİCİOĞLU, İsmail AYDIN, Selahattin VURAL, İlkay ÇİNAR, Mehmet GÜLMEZ, Arif KESKİN

Pages : 23-30

Doi:10.19127/mbsjohs.1008275

View : 21 | Download : 6

Publication Date : 2022-02-25

Article Type : Research Paper

Abstract :Objective : We aimed to investigate Hypericum Perforatum insert ignore into journalissuearticles values(St. John`s Wort Oil); and pure olive oil with respect to their effect on preventing intra-abdominal adhesions after abdominal surgery. Methods: This was an animal study carried out by the Giresun Faculty of Medicine, Department of General Surgery between August 10, 2020, and September 10, 2020. In the study, intra-abdominal adhesion development was examined macroscopically and microscopically on the 14th day after experimental abdominal surgery in three groups [insert ignore into journalissuearticles values(i); Control, insert ignore into journalissuearticles values(ii); olive oil application, insert ignore into journalissuearticles values(iii); St. John`s Wort oil application] each consisting of 7 female Wistar Albino rats. Majuzi classification and Zuhlke`s microscopic adhesion classification was used to evaluate adhesions. Results: Macroscopically, fibrous bands were not observed in 1 rat in the control group, 2 rats in olive oil recipients, and 1 rat in St. John`s Wort oil recipients. A significant difference between the groups was identified in terms of Zuhlke`s microscopic adhesion scores insert ignore into journalissuearticles values(p = 0.026);. Accordingly, the adhesion level was significantly reduced in olive oil recipients compared to controls insert ignore into journalissuearticles values(p = 0.002);. There was no significant difference in terms of adhesion between all groups insert ignore into journalissuearticles values(p>0.05);. The Majuzi adhesion classifications in the control group, olive oil group and St. John`s wort groups were also similar insert ignore into journalissuearticles values(p = 0.308);. Conclusion: In rats who underwent abdominal surgery, it was determined that intra-abdominal olive oil application reduced the level of adhesion, while St. John`s Wort oil application had no effect on adhesion formation.
Keywords : Abdominal Surgery, Adhesion, St John, Olive Oil