Effect of Sodium Fluorescein Use on Surgical Outcomes and Survival in Cases with High Graded Glial Tumor : A retrospective study

Authors : Tamer TUNÇKALE, Tezcan ÇALIŞKAN

Pages : 592-602

Doi:10.19127/mbsjohs.1143930

View : 13 | Download : 5

Publication Date : 2022-11-30

Article Type : Research Paper

Abstract :Objective: The most effective factor on malignant glioma insert ignore into journalissuearticles values(MGs); treatment affecting overall survival is the extent of resection. The use of sodium fluorescein insert ignore into journalissuearticles values(FL); staining in order to increase the amount of resection, is applied more effectively and safely at lower doses with the aid of 560nm filtered surgical microscopes. Our aim was to investigate the effects of the use of FL in MGs surgery on the gross total resection rate insert ignore into journalissuearticles values(GTR);, duration of surgery, length of hospital stays, and survival time. Methods: A retrospective study was conducted on 17 patients whose histopathological evaluations were reported as MGs and operated under surgical white light insert ignore into journalissuearticles values(Group 1);, and 23 patients who were operated under FL560 module surgical microscope insert ignore into journalissuearticles values(Group 2); with a low dose of insert ignore into journalissuearticles values(3mg/kg body weight); FL dye. The blood loss in the course of surgery, GTR, surgical time, and hospital stay were compared for both groups with the student-t-test. Kaplan-Meier method was used for the survival time analysis. Results: GTR rates were found to be 82.3% for patients operated under surgical white light, and the percentage for FL-utilized patients was 91.3%. There was no significant difference in blood loss or hospital stay between the two groups; however, the surgical time for FL-utilized patients was found to be significantly low in comparison to the other group. The overall survival time for patients who were operated under surgical white light was found to be 64 weeks insert ignore into journalissuearticles values(448 ± 64 days); while it was determined as 84.7 weeks insert ignore into journalissuearticles values(593±55 days); for patients operated with the use of FL, however, the difference between them was not found out to be statistically significant. The use of FL enabled the surgeon to determine the cortical incision area in 13 cases, where the location of the tumor was close to the cortex. Conclusions: While the use of FL shortens the surgical time in contrast-enhancing MGs, it increases the GTR rate. FL also functions well with the determination of the location of the surgical site for tumors close to the cortex.
Keywords : sodium fluorescein, high grade glioma, surgical resection