The Impact of Carbon Monoxide İntoxication on Thiol/Disulfide Hemostasis

Authors : Özge Ebru DAĞCI VARHAN, Gülşah ÇIKRIKÇI IŞIK, Mustafa EKİCİ, Tuba ŞAFAK, Şeref Kerem ÇORBACIOĞLU, Yunsur ÇEVİK

Pages : 480-488

Doi:10.19127/mbsjohs.1280857

View : 24 | Download : 47

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Objective: Carbon monoxide insert ignore into journalissuearticles values(CO); poisoning is an oxidative stress factor. The aim of the study is to evaluate impact of CO intoxication on thiol/disulfide homeostasis insert ignore into journalissuearticles values(TDH);, an important antioxidative system of the body. Methods: This is a prospective study included 84 participants in each group. Blood samples were taken two time in study group insert ignore into journalissuearticles values(CO intoxication group);, before and at the end of the 3rd hour of normobaric oxygen therapy and once in the control group. TDH parameters were studied with an automated assay developed by Erel et al. Statistical analysis done with SPSS program. Results: Among thiol/disulfide homeostasis parameters, in study group native insert ignore into journalissuearticles values(sh); and total thiol insert ignore into journalissuearticles values(tt); levels in samples taken at the beginning of the oxygen treatment were significantly higher than sh and tt levels of the control group [Study group sh: 399.70 μmoll−1 insert ignore into journalissuearticles values(354.50-423.65);, tt: 439.1 μmoll−1 insert ignore into journalissuearticles values(390.9-467.3); and control group sh: 362.95 μmoll−1 insert ignore into journalissuearticles values(321.95-401.25);, tt: 396.1 μmoll−1 insert ignore into journalissuearticles values(358.5-435);, p=0.01 and p<0.001 respectively]. There was no difference between the groups in term of other TDH parameters. TDH parameters were measured after 3-hour normobaric oxygen treatment, and it was shown sh and tt levels were significantly reduced after treatment. Conclusion: Our study demonstrated that among TDH parameters native and total thiol levels were increasing in patients with CO poisoning and those levels were decreasing in time during normobaric oxygen treatment.
Keywords : carbon monoxide intoxication, Thiol disulfide homeostasis, oxidative stress, antioxidant systems