The Electrospinning of Different Hemostatic Agents and Their Effectiveness

Authors : Başak Ünver Koluman, Mahmed Sari Njjar, Ahmet Koluman

Pages : 1-9

View : 38 | Download : 28

Publication Date : 2024-04-16

Article Type : Research Paper

Abstract :The purpose of this study is to present effective solutions for severe bleeding and tissue damage occurring during situations such as conflicts, disasters, and crises. The aim is to produce nanofibers that can serve as a hemostatic wound dressing, capable of both accelerating wound healing and controlling bleeding. Nanofibers are produced through the electrospinning method by combining hemostatic agents such as adrenaline, Transamin® (TXA), and Ankaferd Blood Stopper® (ABS) with polyvinyl alcohol (PVA) polymer. The morphology, chemical bonding, and hemostatic activity of these nanofibers are extensively analyzed. The feasibility of these nanofibers for medical applications, particularly as wound dressings, was investigated. Results: Field emission scanning electron microscopy (FESEM) images reveal that increased concentrations of adrenaline, TXA, and ABS result in the formation of beaded fibers. While ABS/PVA and TXA/PVA nanofibers have similar average diameters, ABS/PVA exhibits a more beaded morphology. According to hemostatic activity tests, clotting times were similar for adrenaline/PVA and TXA/PVA nanofibers, whereas ABS/PVA nanofibers exhibited a shorter clotting time. Among the findings, adrenaline/PVA nanofibers had the longest clotting time at 4.088 seconds. On the other hand, ABS/PVA nanofibers had the shortest clotting time at 3.819 seconds. An effective hemostatic agent should be able to stop bleeding within 2 minutes after application to the wound site in in vitro settings, without requiring mixing or preparation, and should be easily applicable to wounded areas. The developed hemostatic nanofibers demonstrated the ability to form clots within seconds. The resulting nanofibers from this study will not only contribute to public health but also significantly enhance survival processes.
Keywords : Kanamayı Durdurucular, Kanama Zamanı, Ankaferd Kan Durdurucu, Adrenalin, Traneksamik Asit