Sensitivity of localization studies performed by various radiologists in the evaluation of parathyroid lesions

Authors : Pınar Şişman, Özen Öz Gül, Soner Cander, Ahmet Bilgehan Şahin, Çoşkun Demirtaş, Aybüke Muti, Onur Elbasan, Özlem Saraydaroğlu, Erdinç Ertürk

Pages : 112-117

Doi:10.18621/eurj.308830

View : 20 | Download : 5

Publication Date : 2018-04-04

Article Type : Research Paper

Abstract :Objectives. Preoperative imaging studies are commonly used in the diagnosis of primary hyperparathyroidism to increase the success rate of surgery. In the present study, we aimed to correlate surgical outcomes with the sensitivity of localization studies that were performed by various radiologists. Methods. One hundred eighty-nine patients with preoperative diagnosis primary hyperparathyroidism were included. A total of 174 patients in whom hypercalcemia had been cured by parathyroidectomy, were evaluated retrospectively. In total, 184 lesions were excised from these 174 patients. Ultrasonography insert ignore into journalissuearticles values(USG); and technetium-99m-methoxy isobutyl isonitrile insert ignore into journalissuearticles values( 99m Tc-MIBI); imaging yielded correctly localized lesion in 74 and 108 patients, respectively. Results. The specificity of USG and 99m Tc-MIBI imaging were similar insert ignore into journalissuearticles values(95.9% and 95.0%, respectively);. However, the sensitivity was not satisfactory insert ignore into journalissuearticles values(45.9% for USG, 62.4% for 99m Tc-MIBI);. The gland size was not significant for the rate of lesion detection by 99m Tc-MIBI scan or USG. Significant differences were not observed between the preoperative serum parathormone, serum calcium or 24-hour urine calcium excretion levels and the success rate of localization with either USG or 99m Tc-MIBI. Conclusions. Radiologist experience in ultrasonographic parathyroid imaging was found to affect sensitivity. Therefore, surgeons, radiologists and endocrinologists that perform ultrasonographic evaluation should have extensive experience. 
Keywords : primary hyperparathyroidism, parathyroidectomy, localization studies, ultrasonography, technetium 99m methoxy isobutyl isonitrile