Preoperative hemogram-related parameters to distinguish renal cell carcinoma from benign kidney masses: HERR score

Authors : Ali Rıza TÜRKOĞLU, Yasemin ÜSTÜNDAĞ

Pages : 42-49

Doi:10.18621/eurj.408088

View : 14 | Download : 8

Publication Date : 2019-01-04

Article Type : Research Paper

Abstract :Objectives:   Renal cell carcinoma insert ignore into journalissuearticles values(RCC); accounts for approximately 90% of all kidney malignancies , and it is difficult to preoperatively distinguish between tumors and benign masses without a kidney biopsy in small renal masses. We investigated whether any preoperatively defined hemogram-related parameters had a predictive value that would distinguish RCC from benign kidney masses using a novel scoring method. Methods:  Between January 2011 and November 2017, 330 patients diagnosed with kidney masses and who received an operation were included. Fifty-six masses were benign. The neutrophil-to-lymphocyte count insert ignore into journalissuearticles values(NLR);, platelet -to-lymphocyte count , lymphocyte-to-monocyte count, mean platelet volume , platelet count ratio, and hemoglobin to red cell distribution width ratios were calculated. The hemogram-related parameters were combined with the tumor size to establish the hemogram-related risk insert ignore into journalissuearticles values(HERR); score. The area under the receiver operating characteristics curve, sensitivity, specificity, and likelihood ratios were evaluated to preoperatively diagnose RCC. Results:   Histological findings confirmed RCC in 274 patients. The NLR [median insert ignore into journalissuearticles values(interquartile range);] was higher in patients with RCC, 3.7 insert ignore into journalissuearticles values(4.7);, compared to a benign kidney mass, 2.4 insert ignore into journalissuearticles values(2.2); insert ignore into journalissuearticles values( p < 0.001);. A HERR score cut-off of ≥ 3 showed a good sensitivity at 78% with an LR+ of 10.8 [95% confidence interval insert ignore into journalissuearticles values(CI);: 7.0-16.4] and an LR- of 1.2 insert ignore into journalissuearticles values(95% CI: 1.0-1.5);. Conclusion:   Our study, despite being a preliminary validation, is the first to evaluate hemogram-related parameters for preoperatively discriminating between RCC and benign renal masses, and the HERR score serves as a potential diagnostic biomarker for this.
Keywords : Renal cell carcinoma, kidney mass, hemogram related risk score