Effect of lipid parameters on carotid artery disease progression in patients undergoing carotid endarterectomy and unoperated patients with non-severe carotid artery stenosis

Authors : Kadir Kaan ÖZSİN, Umut Serhat SANRI, Faruk TOKTAŞ, İbrahim Burak ŞEKER, Şenol YAVUZ

Pages : 159-165

Doi:10.18621/eurj.444384

View : 16 | Download : 8

Publication Date : 2019-01-04

Article Type : Research Paper

Abstract :Objectives: We aim to evaluate the relationship between serum lipid indices and carotid artery stenosis insert ignore into journalissuearticles values(CAS);. Methods: This retrospective observational study included patients who underwent carotid endarterectomy insert ignore into journalissuearticles values(CEA); and unoperated patients who have CAS less than 50%. CAS was diagnosed with history and physical examination followed by doppler ultrasonography, coronary and carotid angiography. All data retrieved retrospectively from the hospital medical files. Non-high-density lipoprotein-cholesterol insert ignore into journalissuearticles values(non-HDL-C); level was calculated by removing HDL-C from total cholesterol. In addition, low-density lipoprotein-cholesterol insert ignore into journalissuearticles values(LDL-C);/HDL-C ratio, non-HDL-C/HDL-C ratio, and triglyceride insert ignore into journalissuearticles values(TG);/HDL-C ratio were assessed. Results: CEA group insert ignore into journalissuearticles values(77.5% male, mean age: 71.35 ± 8.35 years); included 40 patients who underwent CEA, and there were 32 patients who have less than 50% CAS in unoperated group insert ignore into journalissuearticles values(68.8% male, mean age: 63.94 ± 9.92 years);. The development of CAS was not significantly correlated with LDL-C/HDL-C ratio insert ignore into journalissuearticles values( p = 0.119);, non-HDL-C/HDL-C ratio insert ignore into journalissuearticles values( p = 0.227); and TG/HDL-C ratio insert ignore into journalissuearticles values( p = 0.768);. Advanced age and presence of coronary artery disease were identified as an independent predictor of the development of CAS. For predicting development of CAS, there were 50.0% sensitivity and 65.6% specificity for LDL-C/HDL-C ratio and non-HDL-C/ HDL-C ratio insert ignore into journalissuearticles values(area under the curve [AUC]: 0.592, log rank p = 0.183, AUC: 0.583, log rank p = 0.227, respectively);. Conclusions: We found that lipid ratios were not an independent predictors of the development of CAS. But, we think that AUC values which were above 0.5 for lipid ratios are may be important development of CAS. 
Keywords : Carotid artery stenosis, lipid levels, disease progression