Dynamic thiol-disulphide homeostasis in grade 3-4 gonarthrosis

Authors : Kenan GÜVENÇ, Şahap Cenk ALTUN, Merve ERGİN, Özcan EREL, Faik İLİK

Pages : 740-744

Doi:10.18621/eurj.414367

View : 11 | Download : 6

Publication Date : 2019-09-04

Article Type : Research Paper

Abstract :Objective: We aimed to determine thiol-disulphide homeostasis, which plays a vital role and to investigate the relationship among homeostatic parameters and disease. Methods: In this prospective study, we enrolled 38 patients with osteoarthritis insert ignore into journalissuearticles values(31 females and 7 males); and 38 healthy controls insert ignore into journalissuearticles values(30 females, 8 males volunteers);. Diagnosis of osteoarthritis was made according to the American College of Rheumatology Criteria. The severity of osteoarthritis was assessed and classified according to the Kellgren-Lawrence grading scale. Results: The mean age was 63.8 insert ignore into journalissuearticles values(range; 53-74); years in the osteoarthritis group and 65.6 insert ignore into journalissuearticles values(range; 55-75); years in the control group. There were no significant differences between the patients and controls in respect to age, gender and body mass index insert ignore into journalissuearticles values( p > 0.05);. Serum albumin insert ignore into journalissuearticles values( p = 0.605); and total protein levels insert ignore into journalissuearticles values( p = 0.605); between patients and controls were similar. In the osteoarthritis group disulphide/ native thiol percent ratios and disulphide/ total thiol percent ratios were found to be statistically higher insert ignore into journalissuearticles values( p = 0.002 and p = 0.002; respectively); and native/ total thiol percent ratios were significantly lower than that of the control group insert ignore into journalissuearticles values( p = 0.002);. Conclusions: Thiol-disulphide homeostasis is weakened in osteoarthritis, and the balance shifts to the disulphide bond formation side. Substitution of thiol deficiency and correction of thioldisulphide imbalance may be beneficial in the managing treatment of the disease. Further studies may be needed for evaluating articular fluid thiol-disulphide homeostasis. 
Keywords : Oxidative stress, osteoarthritis, thiol disulphide homeostasis