Is ischemia modified albumin a good marker in acute exacerbation of chronic obstructive pulmonary disease?

Authors : Nalan OGAN, Togay EVRİN, Tuba ÇANDAR, Aslıhan ALHAN, Meral GÜLHAN

Pages : 388-394

Doi:10.18621/eurj.517778

View : 17 | Download : 7

Publication Date : 2020-09-04

Article Type : Research Paper

Abstract :Objectives: Our aim is to compare the Ischemia modified albumin insert ignore into journalissuearticles values(IMA); in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease insert ignore into journalissuearticles values(COPD); with a high oxidative and inflammatory biologic marker like C-reactive protein insert ignore into journalissuearticles values(CRP); and to investigate its employability in AECOPD and the relationship between arterial blood gas and pulmonary function parameters. Methods: Forty-six patients diagnosed with acute exacerbation of COPD between March 2015 - September 2016 at Ufuk University School of Medicine were included. The 1 st and 5 th days of IMA and CRP levels were measured. Also, IMA levels were given in absorbance units insert ignore into journalissuearticles values(ABSU);. Results: Total 46 patients of COPD, 13 insert ignore into journalissuearticles values(28.3%); were females and 33 insert ignore into journalissuearticles values(71.76%); were males. The mean age of the patients was 71.39 ± 10.04 years. The 1 st and 5 th day values of IMA, ABSU and CRP were 1.08 ± 0.33 and 0.49 ± 0.24; 1.06 ± 0.34 and 0.49 ± 0.26; and 29.25 insert ignore into journalissuearticles values(3.10-288.00); and 6.35 insert ignore into journalissuearticles values(0.30-149.00);, respectively insert ignore into journalissuearticles values( p < 0.001);. No significant correlation was determined between IMA and CRP. Also, no correlation were determined between the parameters of arterial blood gas and pulmonary function. Conclusions: Although IMA values showed significant increase during acute exacerbation of COPD and decreased after treatment, CRP still appeared more effective in evaluating the exacerbation status and following up of the treatment of patients with COPD. 
Keywords : Chronic obstructive pulmonary disease, exacerbation, C reactive protein, ischemia modified albumin