The effect of teicoplanin coating on osteointegration of titanium screws: a biomechanical and histomorphometric study in a rabbit model

Authors : Ali ÇATALBAŞ, Yavuz AKALIN, İsmail Gökhan ŞAHİN, Nazan ÇEVİK, Yüksel ÖZKAN, Alpaslan ÖZTÜRK

Pages : 401-408

Doi:10.18621/eurj.600539

View : 19 | Download : 6

Publication Date : 2020-09-04

Article Type : Research Paper

Abstract :Objectives: The aim of this experimental animal study was to make a biomechanical and histomorphometric evaluation of the effects of titanium screws covered with teicoplanin, which is wanted to prevent the development of infection, on osteointegration of the screw. Methods: Twenty New Zealand white rabbits were randomly separated into 2 groups. In Group 1, 2 mini screws with teicoplanin coating were placed in the femoral condyles of the right knee and in Group 2, 2 mini screws with no coating. After 4 weeks, all the animals were sacrificed and prepared for biomechanical and histological examinations. Results: In the pull-out test, the values of Group 1 were found to be higher and in the removal torque test, the values of Group 2 were higher. No positive correlation was found between the pull-out and removal torque tests insert ignore into journalissuearticles values(r = 0.88);. The bone-implant contact value was found to be similar in both groups insert ignore into journalissuearticles values( p = 0.132);. Conclusions: The results showed that titanium screws with teicoplanin coating did not interfere with osteointegration process biomechanically andhistomorphometrically by comparison with screws having no coating so that teicoplanincoating can be considered for use in orthopedic devices and joint prosthesis to prevent the development of infection. 
Keywords : teicoplanin, osteointegration, histomorphometry, biomechanics, titanium