The relationship between prolactin and adipose tissue and metabolic parameters in patients with polycystic ovary syndrome

Authors : Gültekin ADANAS, Hilal Gülsm TURAN ÖZSOY

Pages : 517-526

Doi:10.18621/eurj.668471

View : 9 | Download : 7

Publication Date : 2020-09-04

Article Type : Research Paper

Abstract :Objectives: Polycystic ovary syndrome is a reproductive endocrinopathy, predominantly accompanied by insulin resistance, obesity, and metabolic disorder. In this study, we aimed to investigate the possible relationship between prolactin and adipose tissue and metabolic parameters in patients with polycystic ovary syndrome insert ignore into journalissuearticles values(PCOS);. Methods: A total of 58 patients with PCOS and 34 body mass index insert ignore into journalissuearticles values(BMI);-matched healthy controls between September 2018 and March 2019 were included in the study. Visceral and subcutaneous adipose tissues were measured using ultrasonography. Serum prolactin, fasting blood glucose, insulin, low-density lipoprotein cholesterol insert ignore into journalissuearticles values(LDL-C);, high-density lipoprotein cholesterol insert ignore into journalissuearticles values(HDL-C);, triglyceride, total cholesterol, luteinizing hormone insert ignore into journalissuearticles values(LH);, total testosterone, dehydroepiandrosterone sulfate insert ignore into journalissuearticles values(DHEA-S);, and 17-hydroxyprogesterone insert ignore into journalissuearticles values(17-OHP); levels were measured. Results: The median BMI insert ignore into journalissuearticles values( p = 0.001);, waist circumference insert ignore into journalissuearticles values( p = 0.002);, hip circumference insert ignore into journalissuearticles values( p = 0.003);, waist-to-hip ratio insert ignore into journalissuearticles values( p = 0.013);, LH insert ignore into journalissuearticles values( p = 0.012);, total testosterone insert ignore into journalissuearticles values( p = 0.004);, DHEA-S insert ignore into journalissuearticles values( p = 0.049);, 17-OHP insert ignore into journalissuearticles values( p = 0.001);, insulin insert ignore into journalissuearticles values( p = 0.001);, minimum preperitoneal fat thickness insert ignore into journalissuearticles values( p = 0.001);, maximum preperitoneal fat thickness insert ignore into journalissuearticles values( p = 0.048);, and intraperitoneal fat thickness insert ignore into journalissuearticles values( p = 0.018); were significantly higher in the PCOS group compared to the control group. However, there was no significant correlation between prolactin levels and adipose tissue parameters and insulin levels in the patients with PCOS. Conclusions: Although there was an increase in the preperitoneal and intraperitoneal fat thickness in the PCOS group compared to the control group, no significant correlation was observed between prolactin and visceral and subcutaneous adipose tissues and metabolic parameters.
Keywords : Prolactin, polycystic ovary syndrome, adipose tissue