The incidence of hypophosphatemia in the early posttransplant period in renal transplant recipients and its association with graft function

Authors : Emel ISIKTAS SAYILAR

Pages : 495-500

Doi:10.18621/eurj.802982

View : 16 | Download : 8

Publication Date : 2021-09-04

Article Type : Research Paper

Abstract :Objectives: To investigate the prevalence of posttransplant hypophosphatemia in the early posttransplant period among renal transplant recipients in relation to its impact on renal graft function. Methods: A total of 78 renal transplant recipients who were transplanted between January 2016 and March 2020 were included in this retrospective single center study. Data on laboratory findings insert ignore into journalissuearticles values(phosphate, creatinine, estimated glomerular filtration rate [eGFR], albumin, serum corrected calcium and parathyroid hormone [PTH] levels); at pre- and posttransplant 3 month follow up period were recorded. Results: Hypophosphatemia was detected in 16 insert ignore into journalissuearticles values(20.8%);, 13 insert ignore into journalissuearticles values(16.7%); and 7 insert ignore into journalissuearticles values(9.1%); patients at the posttransplant day 10, month 1 and month 3, respectively. Posttransplant day 10 and day 30 measurements revealed significantly lower serum creatinine values insert ignore into journalissuearticles values( p < 0.001 and p < 0.07, respectively); and significantly higher eGFR values insert ignore into journalissuearticles values( p = 0.009 and p = 0.036, respectively); in the hypophosphatemic group compared to the normophosphatemic group. Serum phosphate displayed linear relationship with creatinine at day 10 insert ignore into journalissuearticles values(r=0.687, p < 0.001);, day 30 insert ignore into journalissuearticles values(r=0.301, p = 0.007);, while not correlated with PTH levels at posttransplant day 10, day 30 and day 90. Conclusions: Our findings suggest that hypophosphatemia is common in the early posttransplant period, particularly first month after kidney transplantation, being associated with better renal graft function.
Keywords : Hypophosphatemia, kidney transplantation, graft function