A retrospective investigation of the effect of tranexamic acid application and tourniquet duration on postoperative bleeding amount in patients undergoing total knee arthroplasty

Authors : Mustafa Onur KARACA, Abdullah MERTER, Kerem BAŞARIR, Mehmet Bahaddin GÜZEL

Pages : 1-8

Doi:10.18621/eurj.817200

View : 26 | Download : 6

Publication Date : 2022-01-04

Article Type : Research Paper

Abstract :Objectives: It is aimed to investigate the effect of tourniquet and tranexamic acid insert ignore into journalissuearticles values(TXA); on the amount of perioperative bleeding in patients undergoing total knee arthroplasty. Methods: One hundred and ninety-three patients included in the study. The patients included in the study were divided into 4 groups. Group 1 insert ignore into journalissuearticles values(n = 78); was determined as the patient group with long-term tourniquet application, but without additional application and was accepted as the control group. Group 2 insert ignore into journalissuearticles values(n = 40); was the long-term tourniquet and intravenous insert ignore into journalissuearticles values(IV); TXA applied group, Group 3 insert ignore into journalissuearticles values(n = 40); was the long-term tourniquet and intra-articular TXA applied group, and Group 4 insert ignore into journalissuearticles values(n = 35); was the short-term tourniquet insert ignore into journalissuearticles values(only in the cementing phase); and IV TXA applied group. The difference between groups according to use of a tourniquet during the operation, the method and dose of TXA, the amount of postoperative blood transfusion, the amount of drained blood, the length of hospital stay, and complications were investigated. Results: The largest Hemoglobin insert ignore into journalissuearticles values(Hb); and Hematocrit insert ignore into journalissuearticles values(Hct); decreases were found in Group 1 insert ignore into journalissuearticles values(3.39 ± 0.92 g/dl and 10.8%, respectively);. Also the highest drainage insert ignore into journalissuearticles values(median 350 ml);, transfusion insert ignore into journalissuearticles values(16.7%);, length of hospital stay insert ignore into journalissuearticles values(mean 4.51 ± 1.07 days); and estimated blood loss insert ignore into journalissuearticles values(median 1559.8 ml); were in Group 1 insert ignore into journalissuearticles values( p < 0.05);. The lowest Hb decrease insert ignore into journalissuearticles values(mean 2.95 ± 0.68 g/dl); and lowest drainage insert ignore into journalissuearticles values(median 150 ml); was seen in group 3 and the lowest length of hospital stay insert ignore into journalissuearticles values(mean 3.89 ± 0.8 days); in group 4 insert ignore into journalissuearticles values( p < 0.05);. Conclusions: The use of TXA was shown to lead to a reduction in Hb and Hct, the amount of blood drained after surgery, and the length of hospital stay. The use of TXA may be a good option for bleeding control in patients undergoing total knee arthroplasty.
Keywords : arthroplasty, tranexamic acid, tourniquets, drains