The response to double-dose hepatitis B vaccination in patients with HIV

Authors : Melda TURKEN, Tuba TATLI KIŞ, Sabri ATALAY, Şükran KÖSE

Pages : 31-36

Doi:10.18621/eurj.822127

View : 18 | Download : 11

Publication Date : 2022-01-04

Article Type : Research Paper

Abstract :Objectives: Prevention of hepatitis B virus insert ignore into journalissuearticles values(HBV); infection is necessary for patients with human immunodeficiency virus insert ignore into journalissuearticles values(HIV);, since co-infection is associated with increased in mortality. The aim of this study was to investigate response to double-dose HBV vaccine in patients with HIV. Methods: A total of 149 patients with HIV were retrospectively evaluated. Sixty-eight patients who were HBV seronegative and administered double-dose HBV vaccine were included in the study. According to anti HBs levels, patients were evaluated in three groups: < 10 mIU/mL, 10-100 mIU/mL and ≥ 100 mIU/mL. Age, sex, transmission route, smoking, alcohol-substance abuse, comorbidities, CD4+ T cells counts and HIV viral load were compared in three groups. Results: The rate of response to HBV vaccination insert ignore into journalissuearticles values(anti HBs ≥ 10 mIU/mL); was 69.1%. Age was statistically significantly higher in the anti HBs < 100 mIU/mL group than in the anti HBs >100 mIU/mL group. The level of anti HBs was statistically significantly lower in patients with a CD4+ T cell count < 200 cells/μL insert ignore into journalissuearticles values(< 100 mIU/mL);. Conclusions: The use of high-dose vaccine is a necessity as well as revaccination to improve vaccine immunogenicity in patients with HIV. In our study, low CD4+ T lymphocyte count and older age were found to have a negative effect on vaccine response.
Keywords : co infection, HBV, HBV vaccination, HIV, response