A window of opportunity against diabetes: frequency of microvascular and macrovascular complications in prediabetes

Authors : Ulaş Serkan TOPALOĞLU, Mehmet Fatih GÖL, Ender SIRAKAYA, Fatih TANRIVERDİ

Pages : 116-123

Doi:10.18621/eurj.880152

View : 14 | Download : 5

Publication Date : 2023-01-04

Article Type : Research Paper

Abstract :Objectives: To determine the chronic complications of diabetes mellitus insert ignore into journalissuearticles values(DM); in patients with prediabetes, and to compare prediabetics with normoglycemic group participants in terms of the presence of the complications of DM. Methods: An observational study was conducted between December 2018 to April 2019. The patients aged 18-65 years were recruited from an internal medicine outpatient clinic of a tertiary care hospital. A total of 106 prediabetic patients and 54 normoglycemic subjects were included to the study. OGTT-0th, OGTT-2nd and HbA1c levels, lipid parameters, blood pressure, the homeostasis model assessment of insulin resistan insert ignore into journalissuearticles values(HOMA-IR);, body mass index insert ignore into journalissuearticles values(BMI); were estimated. Nephropathy insert ignore into journalissuearticles values(urine protein/urine creatinine ratio, serum creatinine [sCre], Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation-- creatinine clearance);, retinopathy by dilated fundus examination and neuropathy insert ignore into journalissuearticles values(10-g monofilament testing and electroneuromyography [ENMG]); were assessed. Results: Age, gender, BMI, HOMA-IR, smoking status, lipid parameters, systolic blood pressure were similar in both groups. The values of oral glucose tolerance test insert ignore into journalissuearticles values(OGTT);-0th, OGTT-2nd and glycated hemoglobin insert ignore into journalissuearticles values(HbA1c); were higher in prediabetics. Although not statistically significant, proteinuria was slightly more occurred in the prediabetics than the controls. sCre was significantly higher, and CKD-EPI equation was significantly lower in prediabetics than in controls insert ignore into journalissuearticles values( p = 0.012, p = 0.001, respectively);. We did not detected diabetic retinopathy in any participants. Neuropathy was slightly more occured in prediabetics, but it was not significantly different insert ignore into journalissuearticles values( p = 0.309);. There were no correlation between sCre, CKD-EPI, proteinuria and age, BMI, HOMA-IR, OGTT-0th, OGTT-2nd, and HbA1c. Conclusions: Managing the prediabetes by early diagnosis is very meaningful in terms of prevention from DM and its complications. So, prediabetes may be a window of opportunity for diabetes associated morbidity.
Keywords : Complications, Nephropathy, Neuropathy, Prediabetes, Retinopathy