Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients

Authors : Elif ERTURK, Mehmet SARİMAHMUT, Mustafa Şehsuvar GÖKGÖZ, Sahsine TOLUNAY

Pages : 529-535

Doi:10.18621/eurj.1149697

View : 9 | Download : 5

Publication Date : 2023-05-04

Article Type : Research Paper

Abstract :Objectives: Breast cancer is the second leading cause of cancer deaths among women. Therefore, there is a need for new approaches that increase the success of treatment in breast cancer. Cancer stem cells insert ignore into journalissuearticles values(CSCs); are associated with treatment resistance and metastasis, which are important problems in cancer treatment including breast tumors. In this study, the Hematopoietic- and neurologic-expressed sequence 1-like insert ignore into journalissuearticles values(HN1L);, also known as Jupiter microtubule associated homolog 2 insert ignore into journalissuearticles values(JPT2); protein levels which is involved in the self-renewal of CSCs were evaluated in common and rare breast tumor types. Methods: In this context, HN1L protein levels were measured from plasma of 17 patients and from tumor and normal tissues of 9 patients by enzyme linked immunosorbent assay method. Results: Mean HN1L levels were measured as 1.63 ± 0.88 ng/mL in plasma samples, 2.18 ± 0.75 ng/mL in tumor tissue samples and 2.71 ± 0.88 ng/mL in normal tissue samples. A significant difference was observed between mean HN1L levels in plasma and normal tissue insert ignore into journalissuearticles values( p < 0.05);. Correlation of HN1L protein levels with clinicopathological characteristics were analyzed. Accordingly, HN1L levels were positively correlated with tumor size and invasion status insert ignore into journalissuearticles values(r=0.425; p < 0.05 and r=0.449; p < 0.05, respectively);. Conclusions: We believe that the importance of HN1L in management of breast cancers will be demonstrated more thoroughly when further studies are conducted with increased number of patients.
Keywords : HN1L, JPT2, breast cancer, cancer stem cell