Investigation of the genotoxic and antigenotoxic properties of essential oils obtained from two Origanum species by Drosophila wing SMART assay

Authors : Eşref DEMİR, Bülent KAYA, Ricard MARCOS, Serap Kocaoğlu CENKCİ, Hüseyin ÇETİN

Pages : 129-138

Doi:10.3906/biy-1205-64

View : 16 | Download : 9

Publication Date : 2013-12-01

Article Type : Research Paper

Abstract :In this study, essential oils extracted from 2 species of oregano, Origanum onites L. and Origanum minutiflorum O.Schwarz & P.H.Davis, were assayed for genotoxicity using the somatic mutation and recombination test insert ignore into journalissuearticles values(SMART); in Drosophila melanogaster. Results indicated that there is no significant genotoxic effect of the 2 oils tested. In addition, the antigenotoxic activities of these oils against potassium dichromate insert ignore into journalissuearticles values(K2Cr2O7); and cobalt chloride insert ignore into journalissuearticles values(CoCl2); were tested. Results indicated that essential oil cotreatments were able to abolish the genotoxic effects induced by the 2 metal compounds. It is suggested that the observed effects can be linked to the antioxidant properties of the selected essential oils. Moreover, these in vivo results will contribute to the antigenotoxicity database of the 2 Origanum species used in this study.
Keywords : Key words Drosophila, antigenotoxicity, Origanum onites, Origanum minutiflorum, cobalt chloride, potassium dichromate