Acute Effects of Trichloroacetic acid on Serum Enzyme Levels and Erythrocyte Carbonic Anhydrase Activity in Rats

Authors : Halit DEMİR, İsmail ÇELİK

Pages : 121-125

View : 12 | Download : 8

Publication Date : 2006-12-01

Article Type : Research Paper

Abstract :The aim of the present study was to investigate the effects of a sublethal dose of trichloroacetic acid insert ignore into journalissuearticles values(TCA); on serum enzyme levels and erythrocyte carbonic anhydrase insert ignore into journalissuearticles values(CA); activity in rats under laboratory conditions. Ten Sprague-Dawley albino rats were divided in 2 groups of 5 rats. A 200 mg/kg dose of TCA was administered intraperitoneally to the 5 rats in the treatment group. An equal amount of saline solution was injected into the control group. Serum enzyme levels and erythrocyte CA activity of the rats were measured 1, 3, and 6 h after treatment. According to the results, while the TCA sublethal dose treatment caused significant increases in lactate dehydrogenase insert ignore into journalissuearticles values(LDH); and creatine phosphokinase insert ignore into journalissuearticles values(CPK); after 1 and 3 h, aspartate aminotransferase insert ignore into journalissuearticles values(AST); significantly increased after 1, 3, and 6 h. No significant differences in the levels of alanine aminotransferase insert ignore into journalissuearticles values(ALT); and erythrocyte CA were observed in comparison to the controls. It was concluded that TCA may cause toxicity in rats.
Keywords : Trichloroacetic acid, Serum enzymes, Erythrocyte Carbonic anhydrase, Rats