Comparison of Antibacterial Activities of Selected Species of Zingiberaceae Family and Some Synthetic Compounds

Authors : Hiral CHANDARANA, Shipra BALUJA, Sumitra V. CHANDA

Pages : 83-97

View : 7 | Download : 5

Publication Date : 2005-12-01

Article Type : Research Paper

Abstract :This study describes the antibacterial activity of ginger insert ignore into journalissuearticles values(G);, mangoginger insert ignore into journalissuearticles values(M); and turmeric insert ignore into journalissuearticles values(T); and mixtures thereof i.e. ginger and mangoginger insert ignore into journalissuearticles values(GM);, ginger and turmeric insert ignore into journalissuearticles values(GT);, turmeric and mangoginger insert ignore into journalissuearticles values(TM);, and a mixture of peels insert ignore into journalissuearticles values(P); and 4 synthetic compounds insert ignore into journalissuearticles values(HC-1, HC-2, HC-3 and HC-4);. Extracts of these compounds were studied on Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Both aqueous insert ignore into journalissuearticles values(heated and unheated extracts); and organic solvents, 1, 4-Dioxan, N,N,dimethylformamide insert ignore into journalissuearticles values(DMF);, were used for antibacterial assay. Growth inhibition was evaluated by the disc diffusion and agar ditch methods. The antibacterial activity of heated extracts was greater than that of the unheated extracts of all the 3 spices alone or mixtures thereof against all the 3 bacterial strains. When the organic acid extracts were studied, the antibacterial activity of 1, 4-Dioxan extracts of T, GT and TM showed the highest activity against E. coli. The 1, 4-Dioxan and DMF extracts of M showed the highest activity against B. subtilis. The antibacterial activity of G in 1, 4-Dioxan showed the highest activity against S. aureus. Extracts in DMF did not show any activity. The synthetic compounds in 1, 4-Dioxan showed better antimicrobial activity than did DMF extracts. In conclusion, amongst the studied members of Zingiberaceae mangoginger and mixtures containing mangoginger showed maximum antibacterial activity and the synthetic compound HC-3 showed antibacterial activity equivalent to that of mangoginger. Both natural and synthetic compounds extracted in 1, 4-Dioxan gave better results. Therefore, these 2 compounds can be used as lead molecules in drug designing.
Keywords : Zingiberaceae, Antibacterial activity, Natural and synthetic compounds